William Bernal, MD, MPH

Pediatric rheumatologist

Dr. William Bernal is a pediatric rheumatologist, a specialist in caring for children with rheumatic conditions (disorders usually involving inflammation of joints or connective tissues). He is an expert in pediatric amplified pain syndrome and leads the UCSF Pediatric Amplified Pain Rehabilitation Program, an inpatient interdisciplinary approach to relieving pain and restoring function in children disabled by amplified pain.

Bernal's research focuses on patient-reported outcomes and digital health. Specifically, he examines how digital devices can be used to track and improve health.

Bernal earned a master of public health degree in tropical and communicable diseases at the University of South Florida College of Public Health. He earned his medical degree from the Feinberg School of Medicine at Northwestern University. He completed a residency in pediatrics at Children’s Hospital Los Angeles, followed by a fellowship in pediatric rheumatology at Children's Hospital of Philadelphia. He is a member of the American College of Rheumatology.


Pain Management
1825 Fourth St., Fifth Floor, 5A
San Francisco, CA 94143
Phone: (415) 353-1328
Fax: (415) 353-3729

Rheumatology Clinic
1825 Fourth St., Sixth Floor
San Francisco, CA 94158
Appointments: (415) 353-7337
For referring physicians:
(877) UC-CHILD
Fax: (415) 353-2466

More about William Bernal

Additional Languages



Feinberg School of Medicine 2004


Children's Hospital Los Angeles, Pediatrics 2007


Children's Hospital of Philadelphia, Pediatric Rheumatology 2010

Selected Research and Publications

  1. Lisman T, Kleiss S, Patel VC, Fisher C, Adelmeijer J, Bos S, Singanayagam A, Stoy SH, Shawcross DL, Bernal W. In vitro efficacy of pro- and anticoagulant strategies in compensated and acutely ill patients with cirrhosis. Liver Int. 2018 May 16.
  2. Zabron A, Quaglia A, Fatourou E, Peddu P, Lewis D, Heneghan M, Willars C, Auzinger G, Heaton N, Wendon J, Kane P, Karani J, Bernal W. Clinical and prognostic associations of liver volume determined by computed tomography in acute liver failure. Liver Int. 2018 Feb 20.
  3. McPhail MJW, Parrott F, Wendon JA, Harrison DA, Rowan KA, Bernal W. Incidence and Outcomes for Patients With Cirrhosis Admitted to the United Kingdom Critical Care Units. Crit Care Med. 2018 Jan 05.
  4. Connolly B, Maddocks M, MacBean V, Bernal W, Hart N, Hopkins P, Rafferty GF. Nonvolitional assessment of tibialis anterior force and architecture during critical illness. Muscle Nerve. 2017 Dec 20.
  5. Bernal W. Biomarkers for risk assessment in paracetamol hepatotoxicity. Lancet Gastroenterol Hepatol. 2018 Feb; 3(2):76-77.
  6. Lisman T, Bernal W. Management of Hemostatic Disorders in Patients With Advanced Liver Disease Admitted to an Intensive Care Unit. Transfus Med Rev. 2017 Oct; 31(4):245-251.
  7. Spencer CH, Rouster-Stevens K, Gewanter H, Syverson G, Modica R, Schmidt K, Emery H, Wallace C, Grevich S, Nanda K, Zhao YD, Shenoi S, Tarvin S, Hong S, Lindsley C, Weiss JE, Passo M, Ede K, Brown A, Ardalan K, Bernal W, Stoll ML, Lang B, Carrasco R, Agaiar C, Feller L, Bukulmez H, Vehe R, Kim H, Schmeling H, Gerstbacher D, Hoeltzel M, Eberhard B, Sundel R, Kim S, Huber AM, Patwardhan A. Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the Childhood Arthritis and Rheumatology Research Alliance in North America. Pediatr Rheumatol Online J. 2017 Jun 13; 15(1):50.
  8. Bernal W, Wang Y, Maggs J, Willars C, Sizer E, Auzinger G, Murphy N, Harding D, Elsharkawy A, Simpson K, Larsen FS, Heaton N, O'Grady J, Williams R, Wendon J. Development and validation of a dynamic outcome prediction model for paracetamol-induced acute liver failure: a cohort study. Lancet Gastroenterol Hepatol. 2016 11; 1(3):217-225.
  9. Canna SW, Costa-Reis P, Bernal WE, Chu N, Sullivan KE, Paessler ME, Behrens EM. Brief report: alternative activation of laser-captured murine hemophagocytes. Arthritis Rheumatol. 2014 Jun; 66(6):1666-71.
  10. Nayak RR, Bernal WE, Lee JW, Kearns MJ, Cheung VG. Stress-induced changes in gene interactions in human cells. Nucleic Acids Res. 2014 Feb; 42(3):1757-71.
  11. Mizesko MC, Banerjee PP, Monaco-Shawver L, Mace EM, Bernal WE, Sawalle-Belohradsky J, Belohradsky BH, Heinz V, Freeman AF, Sullivan KE, Holland SM, Torgerson TR, Al-Herz W, Chou J, Hanson IC, Albert MH, Geha RS, Renner ED, Orange JS. Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2013 Mar; 131(3):840-8.

Publications are derived from MEDLINE/PubMed and provided by UCSF Profiles, a service of the Clinical & Translational Science Institute (CTSI) at UCSF. Researchers can make corrections and additions to their publications by logging on to UCSF Profiles.