Skip to Main Content

Primary Immune Regulatory Disorder (PIRD) Clinic

The Pediatric Primary Immune Regulatory Disorder (PIRD) Clinic cares for children with complex immune system problems that have a genetic cause. The label PIRD covers a diverse group of rare disorders in which the immune system malfunctions – it is overactive, underactive or doesn’t respond appropriately to challenges.

Depending on the particular genetic mutation, a child with PIRD may develop an autoimmune disorder, a condition in which the immune system attacks healthy tissues; hyperinflammation or autoinflammation, in which the immune system overreacts or reacts without cause; severe allergies; or other conditions in which key immune cells aren’t functioning properly. These conditions usually become apparent in the first years of life and they are difficult to treat, leaving patients vulnerable to disability and death.

Our goal at the PIRD Clinic is to change the common course for these diseases. Directed by Dr. Alice Chan, an expert on PIRD, our team of pediatric specialists works to determine the underlying genetic cause of each patient’s condition. Once we have this diagnosis, we can design a therapy that precisely targets the defective immune system pathway. For example, if our genetic testing shows a defect in the gene that makes CTLA4, an important protein for controlling the immune system, we can treat the patient with a drug that delivers this protein.

For some children with PIRD, the best treatment is a stem cell transplant. In these cases, we collaborate with the team at the UCSF Blood & Marrow Transplant (BMT) Clinic. Finding the best option for each child and family is part of our mission to bring the best care to children with PIRD.

Our locations (1)

    Awards & recognition

    • Ranked among the nation's best in 11 specialties

    Plan your visit

    Preparing for your appointment

    What to Bring

    • Photo I.D.
    • Health insurance card
    • Insurance authorization, if required
    • Doctor's referral, if required
    • Recent test results related to your child's condition
    • List of medications, including dosages, plus any your child is allergic to
    • Immunization record
    • List of doctors and locations seen in the past
    • List of questions you may have
    • Device or paper for taking notes

    For visitors

    Before you head to the hospital, check out our guidelines for visitors and caregivers.

    your-stay-2x

    Your Stay

    We offer valuable information to help you plan for your child's upcoming hospital stay. Find out about food services, family accommodations and more.

    Learn more
    your-childs-care-team-2x

    Your Child's Care Team

    Our doctors, nurses, child life specialists and other providers have special training to care for children. Meet your child's care team.

    Learn more
    interpreters-2x

    Interpreter Services & Communication Assistance

    Interpreter services in many languages and TDDs are available for families that need help communicating with care teams. Here's how to access them.

    Learn more

    Related clinics (4)

    rheumatology-clinic-320x320-2x 4

    Rheumatology Clinic

    Rheumatology Clinic

    Greenbrae / San Francisco / Oakland / Walnut Creek

    immunology-center-320x320-2x

    Immunology Center

    Immunology Center

    1825 Fourth St., Sixth Floor
    San Francisco, CA 94158

    blood-and-marrow-transplant-clinic-320x320-2x 3

    Blood & Marrow Transplant (BMT) Clinic

    Blood & Marrow Transplant (BMT) Clinic

    San Francisco / Oakland

    8

    Inflammatory Bowel Disease (IBD) Program

    Inflammatory Bowel Disease (IBD) Program

    San Francisco / Oakland / Brentwood / San Mateo / San Ramon / Santa Rosa...

    Support services

    Child Life Services

    Activity rooms, pet therapy and more to help kids feel at home.

    Child Life

    Certified child life specialists ease the stress and anxiety of childhood illness through therapeutic play, schooling and family-focused support.

    Family Amenities

    Family-friendly amenities help you relax and take care of yourself while staying close to your child. We offer lounges, kitchens, showers, breastfeeding rooms and more.

    social-services-2x

    Social Services

    Social workers ease the effect of illness, injury and hospitalization on your family with counseling and assistance to help you navigate the challenges.

    activity-rooms-2x

    Activity Rooms

    Activity rooms offer a relaxed environment for children of all ages. Features include a playroom, digital arts studio and teen lounge. Find out more.

    art-therapy-program-2x

    Art Therapy

    Art therapy helps kids and families express themselves, making it easier to cope with pediatric health issues. Group and bedside services are available.

    music-program-2x

    Music Therapy Program

    Board-certified music therapists help kids cope with illness and the feelings that come with it. Find out about group activities and bedside therapy.

    school-program-2x

    School Program

    Our schoolroom services and individual learning programs help children hospitalized at UCSF continue their education and get ready to return to school.

    school-re-entry-program-2x

    School Re-Entry Program

    We help kids return to school after hospitalization by educating staff and students about their needs and recommending needed accommodations. Read more.

    individual-playtime-and-tutoring-2x

    Individual Playtime & Instruction

    If your child can't be around other kids for medical reasons, you can sign up for private sessions in our activity and school rooms. Find out how.

    interpreters-2x

    Interpreter Services & Communication Assistance

    Interpreter services in many languages and TDDs are available for families that need help communicating with care teams. Here's how to access them.

    Family Resource Center

    We help families cope with the challenges of childhood illness and hospitalization in a relaxing environment where parents can get a much-needed break.

    family-support-program-2x

    Parent Support Program

    Weekly activities, including knitting, scrapbooking, chair massage and more, help family caregivers get a much-needed break. Find out more.

    patient-relations-2x

    Patient Relations

    Patient relations reps and nursing supervisors are here to answer questions and address concerns. Learn about your rights, how to reach us and more.

    spiritual-care-2x

    Spiritual Care

    Chaplains help UCSF patients, families and staff cope with the spiritual and emotional challenges of childhood illness. Learn more.

    international-services-2x

    International Services

    If you're coming to UCSF from outside the U.S., we coordinate your child's appointments and provide other helpful services. Here's how to get started.

    Decorative Caduceus

    A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulc...

    Clinical Remission based on the MMS

    Recruiting

    More about this study
    Decorative Caduceus

    A Trial Comparing Unrelated Donor BMT with IST for Pediatric and Young Adult Patients with Seve...

    The median time to failure or death will be compared on the two arms using the log-rank test. Failure of IST is defined as the date that a second definitive therapy was recommended (BMT, second course of ATG) and failure of BMT de...

    Recruiting

    More about this study
    Decorative Caduceus

    Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease

    The achievement of complete healing (CH) 52 weeks after initiation of anti-TNF therapy guided by ROADMAB™ (therapeutic drug monitoring) as evidenced by a composite of all of the following four features below: 1. Endoscopic heal...

    Recruiting

    More about this study
    Decorative Caduceus

    Improving Outcomes and Reducing Disparities for Patients With Inflammatory Bowel Disease Throug...

    The primary outcome is the change in patient activation from baseline, with a 4-point improvement on Patient Activation Measure (PAM) scale considered a minimal clinically important difference (MCID). Patient activation is an asse...

    Recruiting

    More about this study
    Decorative Caduceus

    A Study of Mirikizumab (LY3074828) in Pediatric Participants With Crohn's Disease

    Clinical response based on PCDAI, and endoscopic response based on SES-CD.

    Recruiting

    More about this study
    Decorative Caduceus

    A Study of Mirikizumab (LY3074828) in Pediatric Participants With Moderately to Severely or Act...

    Recruiting

    More about this study
    Decorative Caduceus

    Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatmen...

    The primary endpoint is the incidence of 1-year GVHD free, EFS (GEFS). An event is defined as death due to any cause, primary or secondary graft failure/rejection, or 2nd HCT whichever occurs first. Grade III-IV acute GVHD and chr...

    Recruiting

    More about this study
    Decorative Caduceus

    Study to Evaluate Rilzabrutinib in Adults and Adolescents With Persistent or Chronic Immune Thr...

    Durable platelet response is defined as a proportion of participants able to achieve platelet counts at or above 50,000/μL for ≥ two-thirds of at least 8 non-missing weekly scheduled platelet measurements during the last 12 weeks ...

    Recruiting

    More about this study
    See all clinical trials

    Smell the roses

    Wander outside into our Butterfly Garden in Oakland and our healing gardens at Mission Bay.

    Share